Dr. Astar Winoto is Professor in the Immunology & Pathogenesis
Division at the Department of Molecular and Cell Biology, U.C. Berkeley.
He is also currently the Director of the Cancer Research Laboratory
and the Head of the Immunology & Pathogenesis Division.
Dr. Winoto received his PhD degree from California Institute of
Technology in 1986. He then performed his post-doctoral research
with David Baltimore at Massachusetts Institute of Technology before
he moved to U.C. Berkeley in 1990. His honors include the Searle
Scholar Award, Cancer Research Institute Investigatorship and the
National Science Foundation Presidential Faculty Fellow Award.
Over the years, interests of the Winoto laboratory include gene
transcription, molecular mechanism of apoptosis, immune tolerance
and lymphoma tumorigenesis. Some of his accomplishments include
elucidation of the pathway in apoptosis of developing T cells, elucidation
of the gene organization and transcriptional regulation of the T-cell
receptor alpha/delta genes, in vivo understanding of the death receptor
transduction pathway, characterization of tumorigenesis in PTEN-mediated
T cell lymphomas and the initial cloning of many genes like the
non-classical major histocompatibility class I genes, Sp2 and Sp3
transcription factors and the p19ink4d cell cycle inhibitor.