Molecular Epidemiology Research Project
Molecular Epidemiology Division seeks to understand the association of genetic variation of viruses, mutation of oncogenes or tumor suppressor genes and cancer development – towards preventing the progress of carcinogenesis. Currently, we are focusing study on the hepatocellular carcinoma (HCC), a primary cancer of the liver, including its distribution and etiology. Most of HCC cases are associated with hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and the specific genotype of HBV or HCV is suggested to be associated with an increased risk of HCC development.
Accordingly, our current topics are studies on:
- The association of HBV genotype and/or mutation and HCC development
- The association of HCV genotype and HCC development
We are now performing a cross sectional study by doing genetic analysis of samples from several regions of Indonesia. The samples are collected from asymptomatic HBV or HCV carriers and patients of HBV- or HCV-related chronic hepatitis, cirrhosis and HCC. The cohort study will be carried subsequently to confirm the association of HBV genotype and/or mutation and HCC development. For this purpose, Molecular Epidemiology Division is prepared with samples storage and database systems, and standard equipment for molecular analysis such as ordinary and Real-Time PCR machines, Imaging System and DNA sequencer.